What is a potential adverse effect of chronic use of potent topical corticosteroids?

Chronic use of potent topical corticosteroids is associated with skin atrophy, particularly in intertriginous areas, which are the skin folds where the skin rubs together, such as under the arms, in the groin, or under the breasts. The use of these strong corticosteroids can lead to a thinning of the epidermis, making the skin more susceptible to injury and easier to damage. This atrophy can present as visible skin changes, such as transparency, a reduction in skin elasticity, and increased fragility.

Understanding this adverse effect is crucial, especially for healthcare providers advising patients on long-term corticosteroid use. Monitoring for signs of atrophy and adjusting treatment approaches if necessary is vital to prevent permanent skin damage.