What condition should a 72-year-old woman taking a thiazide diuretic and a SSRI be monitored for?

Monitoring for hyponatremia in a 72-year-old woman taking a thiazide diuretic and an SSRI is crucial due to the interactions and effects both medications can have on electrolyte levels.

Thiazide diuretics are known to increase the risk of hyponatremia because they promote the excretion of sodium. These diuretics can lead to an imbalance in sodium levels, particularly in older adults, as they may already have decreased renal function or other underlying health issues that predispose them to electrolyte imbalances.

Additionally, SSRIs, while often used to treat depression and anxiety, have been associated with the syndrome of inappropriate antidiuretic hormone secretion (SIADH), which can further contribute to lower sodium levels. In this context, the combined use of a thiazide diuretic and an SSRI increases the risk of developing hyponatremia through both medication mechanisms.

Monitoring sodium levels in this patient is essential to prevent complications related to hyponatremia, such as confusion, seizures, or even coma. Given her age and the complexity of multiple medication regimens, healthcare providers must be vigilant in assessing her electrolyte status regularly.